We are told that as long as radiation is not ionizing, it is not destructive to cells and can therefore do no harm to human and animal physiology. The whole idea of exposure limits is based on this knowledge and a huge increase in communications related technological radiation in the microwave band has been built up in the last few decades. A period of time that also coincides with a huge increase in autism and related developmental disorders.
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HOW
ELECTROMAGNETICALLY INDUCED
CELL LEAKAGE MAY CAUSE
AUTISM
Andrew Goldsworthy May 2011
What is autism?
Autism is a group of life-long
disorders (autistic spectrum disorders or ASD) caused by brain malfunctions. It is associated with subtle changes in brain anatomy (see Amaral et al. 2008 for a review). The core
symptoms are an inability to communicate adequately with others and include
abnormal social behaviour, poor verbal and non-verbal communication, unusual
and restricted interests, and persistent repetitive behaviour. There are also
non-core symptoms, such as an increased risk of epileptic seizures, anxiety and
mood disorders. ASD has a strong genetic component, occurs predominantly in
males and tends to run in families.
Genetic ASD may be caused by calcium entering neurons
It has been hypothesised that some genetic
forms of ASD can be accounted for by known mutations in the genes for ion
channels that result in an increased background concentration of calcium in
neurons. This would be expected to lead to neuronal hyperactivity, the
formation of sometimes unnecessary and inappropriate synapses, which in turn
can lead to ASD (Krey and Dolmetsch 2007).
Electromagnetic fields let calcium into neurons too
There has been a 60-fold increase in ASD in
recent years, which cannot be accounted for by improvements in diagnostic
methods and can only be explained by changes in the environment. This increase corresponds in time to the
proliferation of mobile telecommunications, WiFi, and microwave ovens as well
as extremely low frequency fields (ELF) from mains wiring and domestic
appliances. We can now explain this in terms of electromagnetically-induced
membrane leakage leading to brain hyperactivity and abnormal brain development.
Non-ionising radiation makes cell membranes leak
The first effect of non-ionising
electromagnetic radiation is to generate small alternating voltages across the
cell membranes, which destabilize them and make them leak. This can have all
sorts of consequences as unwanted substances diffuse into and out of cells
unhindered, and materials in different parts of the cell that are normally kept
separate, become mixed.
Why weak fields are more damaging than strong ones
We have known since the work of Suzanne
Bawin and her co-workers (Bawin et al. 1975)
that modulated radio-frequency electromagnetic radiation that is far too weak
to cause significant heating can nevertheless remove calcium ions (positively
charged calcium atoms) from cell membranes in the brain. Later, Carl Blackman
showed that this also occurs with extremely low frequency electromagnetic
radiation (ELF) but only within one or more "amplitude windows", above and below which there is little or no
effect (Blackman et al. 1982;
Blackman 1990). A proposed molecular
mechanism for this can be found in Goldsworthy (2010). In particular, it
explains why weak electromagnetic fields can have a greater effect than strong
ones and why prolonged exposure to weak fields (where cells are maintained in
the unstable condition for longer) is potentially more damaging than relatively
brief exposure to much stronger ones.
How
calcium ions stabilize cell membranes
This loss of
calcium is important because calcium ions bind to and stabilize the negatively
charged membranes of living cells. They sit between the negatively charged
components of the cell membrane and bind them together rather like mortar binds
together the bricks in a wall. Loss of just some of these calcium ions
destabilize the membrane and make it more inclined to leak, which can have
serious metabolic consequences. Among these are the effects of membrane leakage
on the neurons of the brain.
How membrane leakage affects neurons
Neurons transmit
information between one another in the form of chemical neurotransmitters that
pass across the synapses where they make contact. However, the release of these
is normally triggered by a brief pulse of calcium entering the cell. If the
membrane is leaky due to electromagnetic exposure, it will already have a high
internal calcium concentration as calcium leaks in from the much higher
concentration outside. The effect of
this is to put the cells into hair-trigger mode so that they are more likely to
release neurotransmitters and the brain as a whole may become hyperactive (Beason
and Semm 2002; Krey and Dolmetsch 2007, Volkow et al. 2011). This may not be a good thing since the brain may
become overloaded leading to a loss of concentration and what we now call
attention deficit hyperactive disorder (ADHD).
How does this impact on autism?
Before and just after its birth, a child's brain is essentially a blank canvas, and it goes through an intense period of learning to become aware of the significance of all of its new sensory inputs, e.g. to recognise its mother's face, her expressions and eventually other people and their relationship to him/her (Hawley & Gunner 2000). During this process, the neurons in the brain make countless new connections, the patterns of which store what the child has learnt. However, after a matter of months, connections that are rarely used are pruned automatically (Huttenlocher & Dabholkar 1997) so that those that remain are hard-wired into the child's psyche. The production of too many and often spurious signals due to electromagnetic exposure during this period will generate frequent random connections, which will also not be pruned, even though they may not make sense. It may be significant that autistic children tend to have slightly larger heads, possibly to accommodate unpruned neurons (Hill & Frith 2003).
Because the pruning process in electromagnetically-exposed children may be more random, it could leave the child with a defective hard-wired mind-set for social interactions, which may then contribute to the various autistic spectrum disorders. These children are not necessarily unintelligent; they may even have more brain cells than the rest of us and some may actually be savants. They may just be held back from having a normal life by a deficiency in the dedicated hard-wired neural networks needed for efficient communication with others.
A useful homology might be in the
socialisation of dogs. If puppies do not meet and interact with other dogs
within the first four months of their life (equivalent to about two human
years), they too develop autistic behaviour. They become withdrawn, afraid of
other dogs and strangers, and are incapable of normal "pack" behaviour. Once
this four-month window has passed, the effect seems to be irreversible (just
like autism). If this homology is correct, it suggests that experiments on dogs
could hold the key to the investigation of autism and its possible links with
electromagnetic exposure.
References
Amaral DG, Schumann CM, Nordahl CW (2008),
Neuroanatomy of Autism, Trends in Neurosciences 31: 137-145
Bawin SM, Kaczmarek KL, Adey WR (1975), Effects of
modulated VHF fields on the central nervous system. Ann NY Acad Sci 247: 74-81
Beason RC, Semm P (2002), Responses of neurons to an
amplitude modulated microwave stimulus. Neuroscience Letters 333: 175-178
Blackman CF (1990), ELF effects on calcium homeostasis. In:
Wilson BW, Stevens RG, Anderson LE (eds) Extremely Low Frequency
Electromagnetic Fields: the Question of Cancer. Battelle Press, Columbus, Ohio,
pp 189-208
Blackman CF, Benane SG, Kinney LS, House DE, Joines WT
(1982), Effects of ELF fields on calcium-ion efflux from brain tissue in vitro.
Radiation Research 92: 510-520
Goldsworthy A (2010) , Witness Statement, http://mcs-america.org/june2010pg910111213141516.pdf
Hawley T, Gunner M (2000), How early experiences affect
brain development. http://tinyurl.com/5u23ae
Hill EL, Frith U (2003), Understanding autism: insights
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Huttenlocher PR, Dabholkar AS (1997) Regional differences in synaptogenesis in human cerebral cortex. J Comparative Neurology 387 167-178
Krey JF, Dolmetsch RE (2007) Molecular mechanisms of autism: a possible role for Ca2+ signaling. Current Opinion in Neurobiology. 17: 112-119
Volkow ND, Tomasi D, Wang
G, Vaska P, Fowler JS, Telang F, Alexoff D, Logan J, Wong C (2011), Effects of Cell Phone Radiofrequency Signal Exposure
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